Fig. 2.

MMP-2−/− mice do not sustain significantly increased hepatocellular damage after liver injury. Serum levels of markers of hepatocellular injury, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), measured in MMP-2+/+ and MMP-2−/− mice 48 h after one dose of CCl₄ (a) (n = 8 per group) and 48 h after last dose of CCl₄ in chronic CCl₄ administration (b) (n = 4 per group). No statistically significant difference in AST or ALT was noted after either acute or chronic CCl₄ injury, though an increasing trend was observed in the chronic injury model. Data represent means ± SEM