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Breeding scheme for the generation of experimental animals. Original mutants with a mixed genetic background (strain 129 from embryonic stem cells and strain C57BL/6 from cross breeding) were made congenic in C57BL/6 by backcrossing. Due to an unexpected reduction of mutant viability in the C57BL/6 background, the FVB/N strain was introduced to provide viable mutants (Δ/T93M) and controls (+/T93M) with a mixed C57BL/6 and FVB/N background.
