TABLE 2.
Sterols in hair, skin and serum of Litter 2 mice at 7 weeks of age.
| Sterol and Ratio | Hair (μg/g) | Skin (μg/g) | Serum (μg/ml) | |||
|---|---|---|---|---|---|---|
| SLOS1 | Normal1 | SLOS | Normal | SLOS | Normal | |
| Cholesterol | 1500±100 | 2200±100 | 840±30 | 790±80 | 430±70 | 510±30 |
| 7DHC | 730±50 | <1 | 70±30 | <1 | 16±10 | <0.1 |
| Ratio 7DHC/C | 0.48±0.07 | NA | 0.08±0.04 | NA | 0.04±0.04 | NA |
| Desmosterol | 550±902 | 2400±160 | <1 | <1 | <0.1 | <0.1 |
| 7DHD | 1300±1502 | 50±10 | <1 | <1 | <0.1 | <0.1 |
| Ratio 7DHD/D | 2.4±0.2 | 0.020±0.03 | NA2 | NA | NA | NA |
| Lathosterol | 160±802 | 200±30 | 110±90 | 270±150 | <0.1 | <0.1 |
| Cholest-7,24-dien-3β-ol | 300±302 | 110±30 | <1 | <1 | <0.1 | <0.1 |
| Lanosterol | 100±802 | 80±60 | <1 | <1 | <0.1 | <0.1 |
1
The numbers given are for the concentration (mean±SD) and ratios for three control and three affected mice.
2
Absolute values for 7DHD, lathosterol, cholest-7,24-dien-3β-ol and lanosterol are estimates as TIC peak areas were measured against stigmasterol using a response factor of unity, except for desmosterol where calculated response factor was 1.3.
3
NA: Not applicable.