Table II.
Regions of the genome demonstrating evidence of association with T2D (P<10−5) in a multinomial regression analysis of cases categorized according to obesity
| P-value | Allelic OR (95% confidence interval) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Lead SNP | Chromosome | Location (Mb) | Gene (∼nearest) | Control MAF | Multinomial | Heterogeneity | Logistic | BMI≥30 | BMI>30 |
| rs4506565 | 10 | 114.75 | TCF7L2 | 0.325 | 4.03 × 10−14 | 3.09 × 10−4 | 3.03 × 10−12 | 1.54 (1.38–1.72) | 1.20 (1.08–1.34) |
| rs7193144 | 16 | 52.37 | FTO | 0.397 | 9.23 × 10−13 | 7.21 × 10−7 | 2.77 × 10−8 | 1.07 (0.96–1.19) | 1.48 (1.33–1.64) |
| rs11176733 | 12 | 66.10 | ∼CAND1 | 0.063 | 2.20 × 10−6 | 2.90 × 10−6 | 4.10 × 10−2 | 0.84 (0.67–1.05) | 1.51 (1.26–1.82) |
| rs7132840 | 12 | 69.70 | ∼PTPRR | 0.457 | 4.65 × 10−6 | 1.21 × 10−2 | 1.93 × 10−5 | 1.30 (1.17–1.45) | 1.11 (1.00–1.22) |
| rs901130 | 15 | 72.36 | CCDC33 | 0.301 | 5.53 × 10−6 | 3.18 × 10−4 | 7.97 × 10−4 | 0.98 (0.87–1.10) | 0.75 (0.67–0.84) |
| rs9465871 | 6 | 20.83 | CDKAL1 | 0.178 | 5.61 × 10−6 | 5.86 × 10−1 | 1.02 × 10−6 | 1.32 (1.16–1.50) | 1.26 (1.11–1.44) |
| rs387896 | 12 | 5.67 | TMEM16B | 0.106 | 8.70 × 10−6 | 1.22 × 10−1 | 4.80 × 10−6 | 0.78 (0.65–0.95) | 0.65 (0.53–0.79) |
Results are presented for the lead SNP in each region, including MAF in control samples, P-values for tests of association with T2D in multinomial and logistic regression frameworks, P-value for test of heterogeneity of odds ratios for T2D between obese and non-obese cases, and odds ratios (95% confidence intervals) for the minor allele in obese and non-obese cases.