Table 3.

Differentially expressed paracrine factors in bone marrow-derived mesenchymal stem cells versus dermal fibroblasts

Human dermal fibroblast- or BM-MSC-conditioned medium under hypoxic conditions for 24 hours was analyzed with ABBPA and ELISA. The intensity of each dot was measured. “−”, not detected; ±, weakly detected; + to ++++, intensity of positive detection.

Abbreviations: ABBPA, antibody-based protein array; Ang; angiopoietin; BDNF, brain-derived neurotrophic factor; BM-MSC, bone marrow-derived mesenchymal stem cell; EGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; FGF, fibroblast growth factor; Flt-3 ligand, FMS-related tyrosine kinase 3 ligand; IL, interleukin; GDNF, glial cell line-derived neurotrophic factor; GRO, growth-related oncogene; HGF, hepatocyte growth factor; IGF, insulin-like growth factor; IGFBP, IGF binding protein; KGF, keratinocyte growth factor; LIF, leukemia inhibitory factor; MIP, macrophage inflammatory protein; NAP-2, neutrophil-activating peptide; OPTGRN, osteoprotegrin; OSM, oncostatin M; PDGF-BB, platelet-derived growth factor-BB; TGF, transforming growth factor; TPO, thrombopoietin; VEGF, vascular endothelial growth factor.