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. 2010 Nov;136(5):529–540. doi: 10.1085/jgp.201010528

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© 2010 Reisert

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Figure 5. — Suppression of basal firing by an inverse agonist. (A) Suction pipette recordings of an I7-expressing ORN. Application of cycloheptanecarbaldehyde (chca, 100 µM), previously described as an I7 receptor antagonist (Peterlin et al., 2008), suppressed all basal firing. (B) Power spectra analysis in the absence and presence of chca, 1–15 Hz frequency band shaded in gray. (C) Suppression of noise (ΔVar) is similar with chca and niflumic acid (NA), mean ± SEM, n = 14 for chca and 11 for NA. (D) chca does not reduce the response when coapplied with heptanal (both odorants at 100 µM). Only preapplication (5 s) of the antagonist leads to response reduction. (E) Black and green traces are recorded before and after chca application. All recordings are from the same ORN.