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. 2010 Oct 25;207(11):2395–2405. doi: 10.1084/jem.20100995

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© 2010 Abboud et al.

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Figure 2. — LeTx-neutralizing activity of IgG subclasses on RAW264.7 macrophages. Cells were treated with or without LeTx (100 ng/ml PA and 100 ng/ml LF) in the presence or absence of varying amounts of mAb (A), or treated with or without 10 µg/ml mAb in the presence or absence of varying amounts of LF (PA at fixed saturating concentrations, 100 ng/ml; B) or PA (LF at fixed saturating concentrations, 100 ng/ml; C). Viability was established by MTT assay 4 h after LT treatment. Cells treated with IgG2a and IgG2b mAbs showed statistically significant elevation in protection with cells treated with IgG1 mAb. Significance was determined by Student’s t test. Data shown are representative of three independent experiments. Means and standard deviations of triplicates are shown from one representative experiment out of three (A).