Table 4.
Risk of infection is increased for 'Minimal' CFTR function using any definition of infection with Pseudomonas aeruginosa, mucoid Pseudomonas aeruginosa and Aspergillus fumigatus.
| Total Positive (n included in analysis) |
'Minimal' Function (% of class positive) |
'Residual' Function (% of class positive) |
Adjusted Hazards Ratioa | |
|---|---|---|---|---|
| FirstInfx Pa | 318 (436) | 278 (79.4%) | 40 (46.5%) | 3.17 (2.10, 4.78) |
| ChronInfx Pa | 127 (436) | 118 (33.7%) | 9 (10.5%) | 5.47 (2.20, 13.58) |
| MultiInfx Pa | 229 (436) | 206 (58.9%) | 23 (26.7%) | 3.81 (2.32, 6.28) |
| PersInfx Pa | 228 (436) | 203 (58.0%) | 25 (29.1%) | 3.32 (2.00, 5.50) |
| FirstInfx MPa | 492 (919) | 453 (56.3%) | 39 (33.9%) | 2.93 (2.09, 4.09) |
| ChronInfx MPa | 230 (919) | 217 (27.0%) | 13 (11.3%) | 3.85 (2.00, 7.39) |
| MultiInfx MPa | 381 (919) | 354 (44.0%) | 27 (23.5%) | 3.11 (2.09, 4.62) |
| PersInfx MPa | 371 (919) | 345 (42.9%) | 26 (22.6%) | 3.14 (2.06, 4.76) |
| FirstInfx Asp | 451 (1090) | 427 (44.0%) | 24 (20.0%) | 3.77 (2.24, 6.35) |
| ChronInfx Asp | 89 (1090) | 88 (9.1%) | 1 (0.8%) | 18.97 (3.73, 96.43) |
| MultiInfx Asp | 252 (1090) | 237 (24.4%) | 15 (12.5%) | 3.22 (1.73, 5.98) |
| PersInfx Asp | 254 (1090) | 243 (25.1%) | 11 (9.2%) | 4.83 (2.47, 9.46) |
Definition of abbreviations: Pa: Pseudomonas aeruginosa, MPa: mucoid Pseudomonas aeruginosa, Asp: Aspergillus fumigatus, FirstInfx: one positive culture for the organism; MultiInfx: three or more positive cultures for the organism; PersInfx: at least one positive culture for the organism in two of three consecutive years; ChronInfx: three positive cultures within 6 months each positive culture at least 1 month from the last positive culture.
a: Adjusted for FEV1BeforeInfx and number of cultures.