Table 5.
Lung strataa specific hazard ratios for the association of presence of an infection with class mutation status
| Multivariate regressionb | Lung Function <0.50c | Lung Function 0.50-0.75c | Lung Function 0.75-0.9c | Lung Function >0.9c | |
|---|---|---|---|---|---|
| Pa | 3.17 (2.10, 4.78) | 1.59 (0.78, 3.24) (n = 81) | 3.74 (1.70, 8.22) (n = 112) | 4.17 (1.45, 12.0) (n = 110) | 4.01 (1.92, 8.36) (n = 133) |
| MPa | 2.93 (2.09, 4.09) | 1.59 (0.78, 3.22) (n = 192) | 3.80 (2.07, 6.98) (n = 227) | 4.23 (2.01, 8.92) (n = 246) | 3.83 (2.06, 7.11) (n = 255) |
| Asp | 3.78 (2.24, 6.37) | 2.85 (0.77, 10.63) (n = 250) | 10.22 (3.25, 32.21) (n = 282) | 4.51 (1.46, 13.92) (n = 269) | 2.82 (1.34, 5.93) (n = 289) |
| Sa | 1.70 (1.13, 2.53) | 3.41 (1.43, 8.16) (n = 74) | 1.05 (0.54, 2.03) (n = 83) | 0.90 (0.40, 2.06) (n = 66) | 1.94 (1.02, 3.70) (n = 64) |
| MRSa | 2.27 (1.37, 3.75) | 2.04 (0.71, 5.87) (n = 237) | 2.06 (0.84, 5.05) (n = 262) | 1.80 (0.76, 4.30) (n = 260) | 3.40 (1.41, 8.21) (n = 273) |
| Atyp | 2.33 (1.06, 5.12) | 2.12 (0.27, 16.66) (n = 265) | 5.41 (0.42, 70.41) (n = 294) | 1.40 (0.52, 3.78) (n = 292) | 2.47 (1.06, 5.72) (n = 303) |
| Sm | 3.27 (1.95, 5.47) | 2.70 (0.88, 8.31) (n = 229) | 3.62 (1.52, 8.62) (n = 257) | 2.45 (1.12, 5.33) (n = 260) | 3.64 (1.31, 10.13) (n = 247) |
| Ax | 2.57 (1.25, 5.26) | 1.94 (0.42, 9.05) (n = 252) | 8.41 (1.83, 38.58) (n = 282) | 2.07 (0.59, 7.30) (n = 275) | 1.93 (0.64, 5.82) (n = 293) |
| Kp | 3.47 (1.27, 9.48) | 0.28 (0.07, 1.06) (n = 233) | 7.87 e15 (2.30 e15, 2.69 e16) (n = 250) | 7.55 e15 (2.60 e15, 2.19 e16) (n = 247) | 4.73 (1.15, 19.43) (n = 258) |
Definition of abbreviations: Pa: Pseudomonas aeruginosa MPa : mucoid Pseudomonas aeruginosa, Asp: Aspergillus fumigatus, Sa: Staphylococcus aureus, MRSa: Methicillin resistant Staphylococcus aureus, atyp: Atypical mycobacteria, Sm: Stenotrophomonas maltophilia, Ax: Achromobacter xylosoxidans, Kp: Klebsiella pneumoniae.
a: Individual subjects may be in different strata for each infection as the value for the lung function variable reflects the maximal value in the year preceding acquisition of each of the organisms.
b: Cox regression adjusted for FEV1BeforeInfx and number of cultures per year for the subject; comparing 'Residual' function to 'Minimal' function.
c: Stratified Cox regression adjusted for number of cultures per year for the subject; comparing 'Residual' function to 'Minimal' function in each stratum.