Table 2.
Numbers of choroid plexus epithelial cells during development, including numbers positive for plasma protein and BrdU
| Age | n | Total number of CPECs counted |
PP +ve CPECs |
BrdU +ve CPECs |
PP/BrdU double-labelled CPECs (n = 4) |
|---|---|---|---|---|---|
| P3 |
6 |
1855 ± 260 |
131 ± 36 |
44 ± 3 |
0 |
| P4 |
6 |
2060 ± 125 |
175 ± 12 |
59 ± 7 |
2 ± 1 |
| P5 |
6 |
2675 ± 205 |
216 ± 33 |
76 ± 12 |
6 ± 2 |
| P10 |
6 |
3254 ± 106 |
230 ± 45 |
65 ± 17 |
11 ± 2 |
| P30 |
6 |
7790 ± 928 |
695 ± 113 |
71 ± 10 |
- |
| P45 |
6 |
11104 ± 874 |
512 ± 84 |
80 ± 16 |
24 ± 4 |
| P65 |
6 |
12175 ± 954 |
502 ± 54 |
63 ± 7 |
39 ± 2 |
| p value * | < 0.05 | < 0.05 | < 0.05 | < 0.05 |
Data are mean ± SEM, rounded up to the nearest whole cell, n values refer to the number of animals in each experiment. Cell count data represent the number of cells counted, not the total number of cells in the plexus. At each age, approximately 10% of the entire plexus was counted. For double-labelling experiments, four separate brains were used (see parenthesis). * comparing youngest and oldest ages in each instance. Abbreviations: BrdU, 5-bromo-2-deoxyuridine; CPECs, choroid plexus epithelial cells; P, postnatal days; PP, plasma protein.