Table 4.
Evaluation of tablets* (batch B1–B8)
| Evaluation parameters | Formulations |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| B-1 | B-2 | B-3 | B-4 | B-5 | B-6 | B-7 | B-8 | ||
| Hardness (kg/cm2) | 2.8±0.6 | 2.9±0.6 | 2.9±0.3 | 3.1±0.6 | 3.3±0.3 | 2.8±0.4 | 2.7±0.8 | 2.8±0.3 | |
| Friability (%w/w) | 0.63±0.3 | 0.75±0.3 | 0.81±0.8 | 0.65±0.38 | 0.67±0.2 | 0.53±0.3 | 0.79±0.7 | 0.44±0.3 | |
| Drug content (%w/w) | 98.16±0.8 | 97.05± 0.4 | 98.37±0.2 | 99.16±0.9 | 98.15±0.8 | 100.16±0.2 | 102.11±0.3 | 99.81±0.3 | |
| % Weight variation | 3.45 ±0.7 | 4.04 ±0.6 | 1.43 ±0.4 | 2.08±1.6 | 2.78±0.5 | 2.24 ±0.8 | 3.87±3.9 | 3.18±0.6 | |
| Water absorption ratio | 76.25±0.4 | 66.36 ±0.7 | 88.17±0.3 | 99.36±1.4 | 113.48±0.5 | 92.42±0.8 | 99.14±3.9 | 106.44±0. | |
| Disintegration time (sec) | In vitro | 60±1.0 | 51±0.6 | 30 ±0.6 | 28± 0.8 | 24 ±0.4 | 35 ±0.6 | 29±1.2 | 27± 0.9 |
| In vivo | 76±0.4 | 63±0.4 | 40±0.2 | 35±0.6 | 27±0.6 | 45±0.8 | 36±0.5 | 31±1.1 | |
*
Results are the mean of 3 observations ± SD.