Figure 1.

(A) Giemsa-Trypsin-Giemsa banding and ideogram results show autosomal-balanced reciprocal translocation involving chromosomal regions 8q and 18q. The arrows indicate the breakpoints on derivative chromosomes 8 and 18. (B) Fluorescence in situ hybridization of metaphase spread with the Vysis WCP DNA probes, which hybridize chromosome 8 (Spectrum Green) and chromosome 18 (Spectrum Red). The arrows indicate the derivative chromosomes 8 and 18. (C) Pedigree demonstrates characteristics of autosomal-recessive inheritance