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. Author manuscript; available in PMC: 2010 Oct 27.
Published in final edited form as: Expert Rev Endocrinol Metab. 2010 Jul 1;5(4):603–614. doi: 10.1586/eem.10.3

Figure 3.

Figure 3

Linearized models of Brx-related guanine nucleotide exchange factors (GEFs) and their functional domains.

All Brx-related GEFs contain the GEF domain harboring the DH and PH domains in the mid region of the molecule. Brx, AKAP-Lbc and proto-Lbc contain NRID in their C-terminal end, while AKAP-Lbc has a PKA/Gα12 docking domain in its N-terminal portion. Brx and AKAP-Lbc also contain one 14-3-3-binding site.

DH: Dbl-homology, GEF: guanine nucleotide-exchange factor, NRID: nuclear receptor-interacting domain, PH: pleckstrin-homology, PKA: protein kinase A