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. Author manuscript; available in PMC: 2010 Oct 27.
Published in final edited form as: Expert Rev Endocrinol Metab. 2010 Jul 1;5(4):603–614. doi: 10.1586/eem.10.3

Figure 4.

Figure 4

Linearized models of JIP family proteins and their functional/structural domains.

JIP family consists of 5 members and their splicing isoforms. All have a JNK-binding domain (JBD) in their N-terminal portion, while JIP1 and 2 contain SH3 and PTB domains in their C-terminal end. JIP3 and 4 and JLP have a putative transmembrane domain (TM) in their C-terminal end. JIP4 interacts with Brx through its middle portion enclosing multiple coiled-coil structures.

CC: coiled-coil, JIP: JNK-interacting protein, JLP: JNK-associated leucine zipper protein, JBD: JNK-binding domain, LZ: leucine zipper, PTB: phosphotyrosine-binding domain, SH3: Src homology-3 domain