TABLE 17.

Single channel properties of AMPA, kainate, and NMDA receptors

	POPEN	Open Time	Conductance
		ms	pS
GluA1-flip	0.4–1.01–3	0.2–0.91	8, 15, 23, 311,4–6
GluA2-flip Q7	0.618	0.32, 1.479	7, 15, 24, 369,10
GluA3-flip	0.8211,12
GluA4-flip	0.772,12	0.14, 3.313	9, 20, 31, 4513,14
GluK1 Q7		0.3, 0.615	5, 9, 1415
GluK2 Q7	0.5–1.03,16	0.6, 2.315	8, 15, 2515
GluK1 Q/GluK5		0.315	5, 9, 1715
GluK2 Q/GluK5		0.4, 2.115	7, 13, 2015
GluN1/GluN2A	0.36–0.5017,18,19	0.06, 1.3, 3.620–22	51, 3822
GluN1/GluN2B	0.07–0.1717,19,23	0.6, 2–3.223	51, 3922
GluN1/GluN2C	0.024	0.622	36, 1922
GluN1/GluN2D	0.01–0.0420,25	0.1, 0.9, 2.620	35, 1726
GluN1/GluN2A/GluN2D	0.08–0.2427	0.07, 1.25, 3.027	30, 40, 5027
GluN1/GluN2B/GluN2D	0.02–0.0328,29	2.4–2.828,29	18, 30, 41, 5428,29
GluN1/GluN3B			12, 3730
GluN1/GluN2A/GluN3B		4.431	26, 4831
GluN1/GluN2A/GluN3A		0.1, 4.732	35, 7533/29, 4732

¹ Banke et al. (2000).

² Robert et al. (2001).

³ P_OPEN depends on PKA phosphorylation of Ser845.

⁴ Measurements in cell-attached patches were similar to those in outside-out patches.

⁵ Derkach et al. (1999).

⁶ Prieto and Wollmuth (2010).

⁷ Edited receptors or mutant receptors have a Gln at the QRN site; editing to Arg decreases conductance (Howe, 1996; Swanson et al., 1996).

⁸ Koike et al. (2000).

⁹ Jin et al. (2003).

¹⁰ Zhang et al. (2008a).

¹¹ Sekiguchi et al. (2002).

¹² Predicted from simulations using rate constants; GluA3-flop was predicted to have a P_OPEN value of 0.42.

¹³ Swanson et al. (1997b).

¹⁴ Tomita et al. (2005a).

¹⁵ Swanson et al. (1996).

¹⁶ Traynelis and Wahl (1997).

¹⁷ Chen et al. (1999b).

¹⁸ Popescu et al. (2004).

¹⁹ Erreger et al. (2005a).

²⁰ Wyllie et al. (1998).

²¹ Popescu and Auerbach (2003).

²² Stern et al. (1992, 1994).

²³ Banke and Traynelis (2003).

²⁴ Dravid et al. (2008).

²⁵ Yuan et al. (2009a).

²⁶ Wyllie et al. (1996).

²⁷ Cheffings and Colquhoun (2000).

²⁸ Jones and Gibb (2005).

²⁹ Brickley et al. (2003).

³⁰ Chatterton et al. (2002).

³¹ Sasaki et al. (2002).

³² Perez-Otano et al. (2001).

³³ Das et al. (1998).