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. 2010 Oct 18;120(11):4129–4140. doi: 10.1172/JCI41732

Figure 1. Association of CCL5 with liver fibrosis in humans.

Figure 1

(A) Haplotype analysis of the CCL5 gene in patients with mild (stage F0/F1, 2n = 200) or advanced (stage F2–F4, 2n = 222) liver fibrosis. The overall haplotype distribution is significantly different between patients with mild fibrosis versus subjects with severe fibrosis (P = 0.01). Specifically, the third most common haplotype, CCL5_H3, is significantly more prevalent in individuals with advanced fibrosis (15.4%) compared with patients with mild fibrosis (5.9%, OR 2.83; *P < 0.05). (B) CCL5 mRNA expression is significantly elevated in subjects with advanced HCV-induced fibrosis compared with that of patients with only mild fibrosis (*P < 0.05). (C) The association of CCL5 mRNA expression with liver fibrosis is confirmed in patients with fibrosis due to NASH (*P < 0.05).