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. 2010 Oct 18;120(11):4129–4140. doi: 10.1172/JCI41732

Figure 4. Bone marrow chimeric mice.

Figure 4

(A) WT mice that receive bone marrow from Ccl5–/– mice display significantly reduced liver fibrosis compared with Ccl5–/– or WT animals transplanted with WT bone marrow (n = 7–8/group; original magnification, ×40) (B) The reduced propensity to liver damage of Ccl5–/– → WT mice is also shown by a lower Sirius red–positive area on histology (***P < 0.001), (C) reduced hydroxyproline liver contents (***P < 0.001), and (D) lower ALT values (*P < 0.05). (E) The mRNA expression of fibrosis-related genes, Col1a1, Timp1, and Tgfb1, is also strongly reduced in Ccl5–/– → WT mice compared with that of the other groups (***P < 0.001, **P < 0.01, *P < 0.05).