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. 2010 Oct 18;120(11):3843–3854. doi: 10.1172/JCI42059

Figure 1. NOS2 expression in human breast tumors.

Figure 1

IHC analysis of invasive breast carcinomas for expression of inducible NOS2 (A–D). NOS2 was mainly expressed in the cytoplasm of tumor cells, with some cells showing a marked perinuclear localization of NOS2 protein. NOS2 expression ranged from (A) absent or occasional expression in the tumor epithelium, to (B) moderate expression in numerous tumor cells, to (C and D) a rather strong expression in the tumor epithelium that was either found localized within the tumor or present in most tumor cells. (D) Shown is a tumor with NOS2 expression in both the tumor epithelium and a lymphoid infiltrate (T, tumor epithelium; S, surrounding lymphoid infiltrate). Original magnification, B: ×100, ×200 (inset); A, C, and D: ×200. Counterstain: hematoxylin.