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. 2010 Oct 18;120(11):3843–3854. doi: 10.1172/JCI42059

Figure 6. Induction of EGFR phosphorylation by the NO donor DETA/NO.

Figure 6

(A) DETA/NO (0.5 mM) induced increased phosphorylation of EGFR at tyrosine phosphorylation sites 1045 and 1173, within 60 minutes. (B) Increased NOS2 expression is associated with increased phosphorylation of EGFR at Tyr1173 in human breast tumors. High EGFR phosphorylation at Tyr1173 (pEGFR Tyr1173) was significantly more common in tumors with high NOS2 than in tumors with low NOS2 (IHC analysis; P = 0.033, χ2 test). In tumors with low NOS2: low pEGFR Tyr1173, n = 23 (48%), high pEGFR Tyr1173, n = 25 (52%). In tumors with high NOS2: low pEGFR Tyr1173, n = 41 (32%), high pEGFR Tyr1173, n = 89 (68%).