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. 2010 Oct 1;120(11):4077–4090. doi: 10.1172/JCI42758

Figure 6. HCMV-specific cells show extensive differentiation, but do not become exhausted.

Figure 6

CD8+ T cells from a patient experiencing primary HCMV response and from a healthy latent virus carrier were stained with tetramers specific for HCMV and EBV epitopes. Shown is 1 representative patient of 3 and 1 representative healthy virus carrier of 4 analyzed. (A) CD27. (B) CD28. (C) TIM3. (D) PD1. (E) Expression on total memory and effector CD8+ T cells. Filled gray histograms denote staining of naive CD8+ T cells.