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Model for regulation of IL-12p40 production by triptolide. Triptolide augments TLR4-mediated activation of ERK1/2 and GSK-3β by interfering with the expression of phosphatases MKP-1 and PTEN. ERK1/2 and GSK-3β enhance the phosphorylation of C/EBPα, and its expression because of autoregulation. C/EBPα functions as an inhibitor of p40 transcription via a yet to be elucidated mechanism.
