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. 2010 Oct 27;5(10):e13637. doi: 10.1371/journal.pone.0013637

Figure 1. Androgen responsive tissues, prostate and levator ani muscle, express different sets of miRs.

Figure 1

A. RNA was extracted from prostate and levator ani muscle of intact Sprague Dawley rats (n = 5; 200 g weight) and the expression of 312 miRs was profiled using realtime PCR. miRs that are statistically different (P<0.05) between the two groups are expressed in the heatmap. P1-P5 = prostate of animals 1–5; LA1-LA5 = levator ani of animals 1–5. B. Pharmacologic effects of AR ligands. Sprague Dawley rats (n = 5; 200 g weight) were castrated and treated subcutaneously for 14 days with vehicle (open bars), 3 mg/day SARM-1 (dotted bars), SARM-2 (hatched bars), an inactive SARM-3 (grey bars) and DHT (black bars). Intact vehicle treated animals are represented by checked bars. At sacrifice, organs were weighed and expressed as raw organ weights. Values are expressed as average ± S.D.