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. 2010 Oct 27;5(10):e13663. doi: 10.1371/journal.pone.0013663

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Ahmed et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) No significant increase in MAP was observed in CBA/J x DBA/2 compared to CBA/J x BALB/c control matings. Data were expressed as change in MAP from mating day. CBA/J x DBA/2 mice showed an increase response to an acute a bolus injection of AngII compared to CBA/J x BALB/c mice (*p<0.01). The response to Ang II was expressed as the mean change in MAP from basal values before Ang II injection. (B) Aortic rings from CBA/J x DBA/2 and CBA/J x BALB/c contracted in response to Ang II (* p<0.05). Aortic rings from CBA/J x DBA/2 mice showed increased reduction of the inner diameter in response to Ang II (# different from CBA/J x BALB/c. P<0.05). N = 8–10 mice/experimental group. (C) Staring at day 11 of pregnancy, plasma leptin levels were increased in CBA/J x DBA/2 mice when compared to control CBA/J x BALB/c matings (* p<0.01). This increase was maintained until delivery. Leptin levels in CBA/J x DBA/2 and control matings drop to pre-pregnancy values after parturition. N = 6–8 mice/experimental group.