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Histological examination of 13.5 days old embryos revealed that, when compared to age-matched Wt embryos, Uch37−/− mice showed undeveloped lateral and third ventricles in forebrain area, with associated disorganized development of cortex and midbrain as well as undeveloped mesencephalic vesicle and fourth ventricles in midbrain, with disorganized development of cerebellum and hindbrain.
