Figure 4. The effect of Rpn13 deletion on proteasome function is tissue-specific.

Indicated proteasome activities were measured in protein lysates prepared from the designated tissues (left panels), or in purified 26S preparations with or without epoxomicin as controls (right panels). For the tissue lysates, data were obtained from 7–19 samples of each genotype pooled from at least four independent experiments giving similar results. 26S controls included 3 samples for each treatment. Enzyme activities were normalized to the mean of the Wt or control values and are presented as mean ± SEM. Numbers above bars indicate P values compared to Wts.