Figure 7. Deletion of Rpn13 alters T-cell development.

(A) Hematopoietic cell profile of the indicated tissues harvested from mice with genotypes designated on the figure. Data were obtained from 4–5 month old mice (n = 15–31) and are presented as mean ± SEM. Numbers above bars indicate P values compared to Wt mice. Mono, monocytes; Neutro, neutrophils. (B) Representative picture of thymi from mice of indicated genotype demonstrating difference in size of the organs. (C) Representative flow cytometric plots show normal CD4/CD8 mAb staining patterns of thymocytes from mice of both genotypes. Samples from 10 additional mice of each genotype gave similar results.