Table 1. Potential LRRK2 substrates.
Protein | Site | Sequence | Score |
Serine-protein kinase ATM (Ataxia telangiectasia mutated) | 1769 | AYLQPFRTSRKKFLE | 0.13 |
Microtubule-associated protein 2 (MAP 2) | 1433 | RKEKPFKTGRGRIST | 0.14 |
ADAM 29 precursor (A disintegrin and metalloproteinase domain 29) | 161 | SEEKQFSTMRSGFMQ | 0.15 |
Fanconi anemia group C protein (FACC protein) | 171 | NHLNGFNTQRRMAPE | 0.16 |
Pancreatic lipase | 83 | ISGSNFKTNRKTRFI | 0.17 |
Cartilage leucine-rich protein | 350 | FRSCKFPTKRSKKAG | 0.18 |
Homeobox protein Nkx-3.2 | 261 | FQNRRYKTKRRQMAA | 0.18 |
Homeobox protein Nkx-3.1 | 179 | FQNRRYKTKRKQLSS | 0.19 |
Chromodomain-helicase-DNA-binding protein 2 | 197 | RVKKQPKTQRGKRKK | 0.19 |
Serine/threonine-protein kinase WNK4 | 1196 | LSKGSFPTSRRNSLQ | 0.20 |
Protein C21orf5 | 2256 | TLNGAFKTQRQLPAD | 0.22 |
Lactase-phlorizin hydrolase | 1914 | KRSKQGKTQRSQQEL | 0.23 |
Splicing factor arginine/serine-rich 11 (p54) | 332 | TPPKSYSTARRSRSA | 0.23 |
Ubiquitin protein ligase Praja1 | 74 | RSRSPFSTTRRSWDD | 0.23 |
5-oxoprolinase | 622 | DMLRAFGTSRQARGL | 0.24 |
Syntabulin | 560 | TVLWAFSTQRGGTDP | 0.24 |
Serine/threonine-protein kinase ULK1 | 456 | QSPTQFQTPRSSAIR | 0.24 |
Cylicin II | 45 | PKPQRPGTKRRSKPS | 0.24 |
Microtubule plus end-directed kinesin motor 3A | 684 | KGKARPKTGRRKRSA | 0.24 |
Ras-related protein Rab-21 | 200 | NGSSQPGTARRGVQI | 0.25 |
Transforming growth factor beta 1 precursor (TGF-beta 1) | 241 | VDINGFTTGRRGDLA | 0.25 |
Dual specificity phosphatase Cdc25A | 288 | EESPPGSTKRRKSMS | 0.25 |
INT-2 proto-oncogene protein precursor (Fibroblast growth factor-3) | 169 | RPRRGFKTRRTQKSS | 0.25 |
Inhibitor of growth protein 1 | 326 | PKEKKAKTSKKKKRS | 0.25 |
Serine/threonine-protein kinase Nek3 | 288 | IKNSKHNTPRKKTNP | 0.25 |
The top-scoring predicted hits that match the LRRK2 phosphorylation consensus were identified using Scansite (scansite.mit.edu).