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. 2010 Oct 27;5(10):e13672. doi: 10.1371/journal.pone.0013672

Table 1. Potential LRRK2 substrates.

Protein Site Sequence Score
Serine-protein kinase ATM (Ataxia telangiectasia mutated) 1769 AYLQPFRTSRKKFLE 0.13
Microtubule-associated protein 2 (MAP 2) 1433 RKEKPFKTGRGRIST 0.14
ADAM 29 precursor (A disintegrin and metalloproteinase domain 29) 161 SEEKQFSTMRSGFMQ 0.15
Fanconi anemia group C protein (FACC protein) 171 NHLNGFNTQRRMAPE 0.16
Pancreatic lipase 83 ISGSNFKTNRKTRFI 0.17
Cartilage leucine-rich protein 350 FRSCKFPTKRSKKAG 0.18
Homeobox protein Nkx-3.2 261 FQNRRYKTKRRQMAA 0.18
Homeobox protein Nkx-3.1 179 FQNRRYKTKRKQLSS 0.19
Chromodomain-helicase-DNA-binding protein 2 197 RVKKQPKTQRGKRKK 0.19
Serine/threonine-protein kinase WNK4 1196 LSKGSFPTSRRNSLQ 0.20
Protein C21orf5 2256 TLNGAFKTQRQLPAD 0.22
Lactase-phlorizin hydrolase 1914 KRSKQGKTQRSQQEL 0.23
Splicing factor arginine/serine-rich 11 (p54) 332 TPPKSYSTARRSRSA 0.23
Ubiquitin protein ligase Praja1 74 RSRSPFSTTRRSWDD 0.23
5-oxoprolinase 622 DMLRAFGTSRQARGL 0.24
Syntabulin 560 TVLWAFSTQRGGTDP 0.24
Serine/threonine-protein kinase ULK1 456 QSPTQFQTPRSSAIR 0.24
Cylicin II 45 PKPQRPGTKRRSKPS 0.24
Microtubule plus end-directed kinesin motor 3A 684 KGKARPKTGRRKRSA 0.24
Ras-related protein Rab-21 200 NGSSQPGTARRGVQI 0.25
Transforming growth factor beta 1 precursor (TGF-beta 1) 241 VDINGFTTGRRGDLA 0.25
Dual specificity phosphatase Cdc25A 288 EESPPGSTKRRKSMS 0.25
INT-2 proto-oncogene protein precursor (Fibroblast growth factor-3) 169 RPRRGFKTRRTQKSS 0.25
Inhibitor of growth protein 1 326 PKEKKAKTSKKKKRS 0.25
Serine/threonine-protein kinase Nek3 288 IKNSKHNTPRKKTNP 0.25

The top-scoring predicted hits that match the LRRK2 phosphorylation consensus were identified using Scansite (scansite.mit.edu).