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. 2010 Oct 27;5(10):e13676. doi: 10.1371/journal.pone.0013676

Figure 5. cis-UCA does not ameliorate colitis in IL-10−/− mice.

Figure 5

129Sv/EV IL-10−/− mice were injected subcutaneously along the dorsal axis every 2 days for 24 days with either 5 or 50 µg cis-UCA, or vehicle (PBS) (n = 5–8). Mice were weighed every second day. cis-UCA had no effect on colonic histological score (A), weight/length ratio (B), MPO levels (C), or IL-17A levels (D). cis-UCA (50 µg) did reduce levels of colonic IFNγ in IL-10−/− mice as compared with PBS or cis-UCA (5 µg) treated (E). *: p<0.05 UCA (50 µg) compared with PBS or UCA (5 µg).