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. 2010 Oct 27;5(10):e15401. doi: 10.1371/journal.pone.0015401

Figure 4. Reversal of pattern completion deficits in DAT+/− mice using haloperiodol after P1 and P2 probe tests.

Figure 4

Normal retrieval in DAT+/− mice under full cue conditions (P3 trials) as measured by target quadrant occupancy (A), platform occupancy (B), and platform crossings (C). No drug was given during this full cue condition test. These mice received two additional trainings on days 13 and 14 (see Figure 1A for probe trial regimen). On the fourth probe trial (P4), DAT+/− mice received systemic injection of a low dose of haloperidol 30 minutes prior the recall tests and the wild-type littermates received a saline injection as a control. Their ability in pattern completion during memory recall was measured by quadrant occupancy (D), platform occupancy (E), and platform crossings (F).These measurements show that DAT+/− mice now can perform as well as the wild-type mice. T: Target quadrant, L: Left quadrant; O: Opposite quadrant; R: Right quadrant. The location of the hidden-platform and one remaining cue hung on the surrounding black curtain wall are illustrated. Either** or *Indicates a significant between-group difference for a given time-point or probe test (**p<0.01, *p<0.05). Either ★★or ★Indicates a significant within-group difference for a given probe test (★★p<0.01, ★p<0.05).