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. 2010 Oct 27;5(10):e15401. doi: 10.1371/journal.pone.0015401

Figure 5. Rescue of pattern completion deficits using haloperiodol in DAT+/− mice which did not receive multiple probe tests.

Figure 5

(A) Normal acquisition of spatial reference memory in two other groups of DAT+/− mice and their control littermates as measured by escape latency. Two other probe tests (P3' and P4') were conducted right after training section. Normal retrieval in DAT+/− mice under full cue condition as measured by target quadrant occupancy (B), platform occupancy (C), and platform crossings (D). No drug was given during this full cue condition test (P1). These mice received an additional block (4 trials) of training one hour after the day 10 full cue probe trial (see Figure 1C for probe trial regimen). On the partial cue trial (P2), DAT+/− mice received systemic injection of a low dose of haloperidol 30 minutes prior the recall tests and the wild-type littermates received a saline injection as a control. Their ability in pattern completion during memory recall was measured by quadrant occupancy (E), platform occupancy (F), and platform crossings (G). These measurements show that DAT+/− mice are now able to perform as well as the wild-type mice. (H) Indistinguishable swimming speed in DAT+/− mice and the control littermates. T: Target quadrant, L: Left quadrant; O: Opposite quadrant; R: Right quadrant. The location of the hidden platform and one remaining cue hung on the surrounding black curtain wall are illustrated. Either** or *Indicates a significant between-group difference for a given point in time or probe test (**p<0.01, *p<0.05). Either ★★or ★Indicates a significant within-group difference for a given probe test (★★p<0.01, ★p<0.05).