Table 3.
Microarray profiling: Partial comparisons between mouse embryo fibroblasts (MEFs, Ikkβ-/- vs. wild type MEFs) and freshly isolated hepatocytes (IkkβΔhep vs. IkkβF/F).
| Gene | MEFs (Ikkβ-/- vs. wt) |
Hepatocytes (IkkβΔhep vs. IkkβF/F) |
GenBank Acc. # | Function |
|---|---|---|---|---|
| X-fold enrichment* | ||||
| CARP | +156.3 | -1.21 | AF041847 | Cardiac ankyrin repeat protein, binding to myopalladin |
| Versican | +9.7 | NR | D45889 | Anti-cell adhesive molecules |
| α-Actin | +2.6 | +1.28 | X13297 | Cytoskeleton, stress fibers |
| Prothymosin β4 | +2.34 | -1.98 | U38967 | Prevents actin polymerization |
| S100A4 | +2.2 | NR | M36579 | Tumor metastasis, calcium-binding protein |
| Tropomyosin 2 | +2.0 | -1.47 | M22479 | Actin-binding protein |
| IGFBP2 | -134 | -1.79 | X81580 | Inhibitor of cell mitogenesis |
| TIMP-2 | -5.8 | -2.32 | X62622 | Inhibitor of matrix metalloproteinases |
| TIMP-3 | -4.0 | -1.99 | U26437 | Inhibitor of matrix metalloproteinases |
| VCAM | -2.9 | +5.62 | M84487 | Vascular cell adhesion molecule |
| Integrin β5 | -2.0 | -1.2 | AF022110 | Cell adhesion |
X-fold enrichment values for MEFs were taken from Chen et al., 2006. The X-fold enrichment value is here in Table 3 defined as the relative comparison of RNA hybridization expression of MEF Ikkβ-/- to MEF Ikkβ+/+, or of IkkβΔhep to IkkβF/F such that a positive (+) value signifies that MEF Ikkβ-/- > MEF Ikkβ+/+, or that IkkβΔhep > IkkβF/F; and, a negative (−) value signifies that MEF Ikkβ+/+ > MEF Ikkβ-/-, or that IkkβF/F > IkkβΔhep. Note that this definition is here the reverse of that in Tables 1 and 2, in order to establish congruence with the E values previously published for the MEF Ikkβ-/- and Ikkβ+/+ pair.