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. 2010 Jun 20;38(19):6577–6588. doi: 10.1093/nar/gkq527

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — mtDNA replication and maintenance (A) The normalized ratios of steady-state levels of replication termination versus replication elongation events of control (C; N = 7) and rescue (R; N = 5) heart samples, as determined by quantitative real-time PCR are shown. Data are presented as means ± SEM percentage of controls; *P < 0.05. (B) Southern blot analysis of mtDNA copy number in comparison with 18S DNA demonstrate a significant reduction of mtDNA levels in KO (8%; N = 7) and heterozygous KO (HET) (62%; N = 3), and a modest reduction in R (80%; N = 8; P = 0.075) in comparison with control samples (N = 10).