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. 2010 Jun 20;38(19):6577–6588. doi: 10.1093/nar/gkq527

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Biochemical measurements of the respiratory chain function in heart tissue. (A) Enzyme histochemical double staining for COX and SDH activities on heart sections of cardiomyopathy, rescue and control mice at 10 weeks of age. Size bar is 100 μm. (B and C) The results from biochemical measurements in hearts from rescue (dark bars) and control (white bars) mice at 12 and 52 weeks of age are shown. Data are presented as means ± SEM percentage of controls with *P < 0.05. (B) Relative enzyme activities of respiratory chain enzyme complexes I and III (NADH cytochrome c reductase, NCR), complex I (NADH coenzyme Q reductase, NQR), complexes II and III (SCR), complex II (SDH) and complex IV (COX). (C) Results from measurements of the MAPR per unit of CS activity in the presence of various substrates: Glutamate + succinate (G + S); TMPD + ascorbate (T + A); palmitoyl-L-carnitine + malate (PC + M); succinate + rotenone (S + R), and succinate (S).