Figure 2.
The N-terminus of Drosha is critical for nuclear localization. (A) Schematic illustration of domain deletion constructs of Drosha tagged with GFP at the N-terminus. (B) Cellular localization of different Drosha deletion mutants. Top panel: nuclear localization of GFP–Drosha with C-terminal 524 amino acid deletion. Upper middle panel: cytoplasmic localization of GFP–Drosha C-terminus. Lower middle panel: nuclear localization of GFP–Drosha N-terminus. Bottom panel: nuclear localization of GFP–Drosha with N-terminal 217 amino acid deletion.
