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. 2010 Aug 4;38(19):e182. doi: 10.1093/nar/gkq687

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Deviation of PB ratios at the yeast chromosome extremities. (A) The genomic distribution of PB ratios (log₂) obtained for TOP1 TOP2 cells and the Δtop1 top2^ts mutant are plotted against the distance (kb) of the corresponding gene to its telomere. Plot trendlines (order 4 polynomial) are shown. (B) The significance of the deviations observed in A is examined by conducting a Student’s t-tests that compares the global PB distribution and that in sliding windows of 200 genes, moving one gene at each step (starting from the chromosomal end). Obtained P-values are plotted against the distance from the telomere of the first gene of each window.