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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Arch Biochem Biophys. 2010 Sep 15;504(2):169–176. doi: 10.1016/j.abb.2010.08.021

Figure 1. X-ray structures of native and latent antithrombins with and without bound pentasaccharide.

Figure 1

-Ribbon models of native (upper panel) and latent (lower panel) antithrombins are shown in the free state (left-hand side, pdb 1E05) and complexed with pentasaccharide (right-hand side, pdb 1E03). The RCL is colored yellow, sheet A is red, helix D is blue and the heparin pentasaccharide is shown in stick and colored magenta. The extension of helix D that accompanies pentasaccharide binding and activation of native antithrombin is colored in cyan. The P14 RCL hinge residue that is buried in sheet A in free native antithrombin and expelled from the sheet in pentasaccharide-activated native antithrombin is shown in space-filling representation.