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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: J Child Psychol Psychiatry. 2011 Apr;52(4):398–408. doi: 10.1111/j.1469-7610.2010.02282.x

Figure 4.

Figure 4

Effect of mother’s history on offspring DNA methylation patterns. Offspring of females that had been maltreated were found to have significantly higher levels of methylated Bdnf DNA in their prefrontal cortex (A) and hippocampus (B) in comparison to offspring from females that had a normal infancy. Data collected in panel A were from methylation-specific real-time PCR (2 Bdnf loci examined), and data collected in panel B were from direct bisulfite sequencing (Bdnf exon IV). (B) Cross-fostering of these offspring (Mal-Normal) did not completely rescue CNS DNA methylation, nor did it induce significant methylation in controls (Normal-Mal). Figure adapted from Roth et al., 2009a.