Table 1.

Global burden of large, rare CNVs

	All CNVs				Deletions only				Duplications only
	ADHD	Controls	Ratio	p value	ADHD	Controls	Ratio	p value	ADHD	Controls	Ratio	p value
All ADHD and controls*
Number of CNVs	57	78	..	..	15	13	..	..	42	65	..	..
Rate	0·156	0·075	2·09	8·9×10−5	0·041	0·012	3·30	0·0018	0·115	0·062	1·85	0·0016
ADHD (IQ ≥70) and controls†‡
Number of CNVs	40	78	..	..	10	13	..	..	30	65	..	..
Rate	0·125	0·075	1·68	0·0077	0·031	0·012	2·58	0·031	0·094	0·062	1·51	0·0387
ADHD (IQ <70) and controls†§
Number of CNVs	14	78	..	..	4	13	..	..	10	65	..	..
Rate	0·424	0·075	5·69	2·0×10−6	0·121	0·012	10·10	0·0012	0·303	0·062	4·88	0·00020

Rate is the average number of CNVs per person. p values are empirical and one-sided. CNV=copy number variant. ADHD=attention-deficit hyperactivity disorder.

^*366 participants with ADHD, 1047 controls.

^†IQ data were unavailable for 14 participants with ADHD.

^‡319 participants with ADHD, 1047 controls.

^§33 participants with ADHD and intellectual disability, 1047 controls.