Table 2.

Association between SNPs and incident coronary heart disease, cardiovascular disease, and myocardial infarction^*

	Region	Candidate gene(s)	Weight†	Reference†	Risk allele	Risk allele frequency	Other allele	Coronary heart disease (total n=19 790)		Cardiovascular disease (total n=24 894)		Myocardial infarction (total n=24 894)
								Pooled HR (95% CI)‡	p value	Pooled HR (95% CI)‡	p value	Pooled HR (95% CI)‡	p value
rs17465637	1q41	MIA3	1·14	15	C	0·75	A	0·99 (0·87–1·12)	0·854	1·03 (0·94–1·12)	0·546	1·03 (0·91–1·18)	0·624
rs11206510	1p32	PCSK9	1·15	15	T	0·84	C	0·94 (0·81–1·09)	0·431	0·97 (0·87–1·07)	0·515	1·04 (0·89–1·22)	0·636
rs646776	1p13	CELSR2–PSRC1–SORT1	1·19	15	T	0·79	C	0·96 (0·84–1·09)	0·512	0·98 (0·89–1·07)	0·587	0·94 (0·82–1·08)	0·378
rs6725887	2q33	WDR12	1·17	15	C	0·11	T	1·14 (0·96–1·35)	0·126	1·00 (0·89–1·12)	0·960	0·96 (0·80–1·14)	0·629
rs9818870	3q22	MRAS	1·15	16	T	0·10	C	0·88 (0·73–1·06)	0·174	0·92 (0·81–1·03)	0·150	0·86 (0·71–1·03)	0·097
rs3798220	6q26	LPA	1·68	18	C	0·01	T	2·07 (1·39–3·09)	3·8×10−5	1·63 (1·22–2·17)	0·001	1·80 (1·19–2·72)	0·005
rs9349379	6p24	PHACTR1	1·12	15	C	0·44	T	1·16 (1·04–1·29)	0·008	1·10 (1·02–1·19)	0·014	1·11 (0·99–1·24)	0·075
rs4977574	9p21	CDKN2A–CDKN2B	1·29	15	G	0·43	A	1·21 (1·08–1·34)	0·001	1·16 (1·08–1·25)	9·3×10−6	1·19 (1·06–1·33)	0·002
rs1746048	10q11	CXCL12	1·17	15	C	0·84	T	1·13 (0·97–1·33)	0·113	1·01 (0·91–1·12)	0·846	1·11 (0·95–1·31)	0·198
rs2259816	12q24	HNF1A	1·08	16	T	0·36	G	1·02 (0·91–1·14)	0·774	1·00 (0·92–1·08)	0·932	1·01 (0·90–1·14)	0·836
rs3184504	12q24	SH2B3	1·13	17	T	0·40	C	1·03 (0·92–1·15)	0·568	1·10 (1·02–1·19)	0·011	1·15 (1·03–1·29)	0·012
rs1122608	19p13	LDLR	1·15	15	G	0·79	T	1·00 (0·87–1·14)	0·988	1·02 (0·93–1·12)	0·693	0·98 (0·86–1·12)	0·774
rs9982601	21q22	SLC5A3–MRPS6–KCNE2	1·20	15	T	0·14	C	1·29 (1·07–1·57)	0·009	1·11 (0·98–1·26)	0·092	1·24 (1·04–1·48)	0·016

SNP=single nucleotide polymorphism. HR=hazard ratio.

^*Association tested with Cox proportional hazards model adjusted for sex, LDL and HDL cholesterol, smoking, body-mass index, systolic and diastolic blood pressure, blood pressure treatment, and diabetes; age was used as the timescale.

^†SNP specific weights for genetic risk score calculation; weights are effect sizes for the SNPs from the studies referenced.

^‡Results from FINRISK 1992, 1997, and 2002, Health 2000, and Malmö Diet and Cancer Cardiovascular Cohort were combined with fixed effects meta-analysis.²¹