Table 3.
Association between genetic risk score and incident coronary heart disease, cardiovascular disease, and myocardial infarction*
|
Genetic risk score quintile |
p value for trend | |||||
|---|---|---|---|---|---|---|
| 1 (reference) | 2 | 3 | 4 | 5 | ||
| HR (95% CI) for CHD (total n=25 243) | ||||||
| FR 1992 | 1·00 | 0·97 (0·65–1·45) | 1·07 (0·71–1·60) | 1·60 (1·10–2·34) | 1·54 (1·06–2·25) | 0·001 |
| FR 1997 | 1·00 | 1·02 (0·72–1·44) | 1·17 (0·84–1·62) | 1·32 (0·95–1·83) | 1·76 (1·28–2·41) | 1·1×10−5 |
| FR 2002 | 1·00 | 1·06 (0·56–1·99) | 1·18 (0·65–2·15) | 1·43 (0·79–2·58) | 1·82 (1·03–3·22) | 0·019 |
| Health 2000 | 1·00 | 0·93 (0·51–1·68) | 1·41 (0·81–2·45) | 1·13 (0·62–2·06) | 1·51 (0·87–2·62) | 0·087 |
| Pooled† | 1·00 | 1·00 (0·80–1·25) | 1·17 (0·94–1·46) | 1·39 (1·12–1·72) | 1·66 (1·35–2·04) | 7·3×10−10 |
| HR (95% CI) for CVD (total n=29 318) | ||||||
| FR 1992 | 1·00 | 1·03 (0·74–1·43) | 1·10 (0·79–1·54) | 1·35 (0·98–1·87) | 1·55 (1·14–2·12) | 0·001 |
| FR 1997 | 1·00 | 0·88 (0·66–1·18) | 1·12 (0·86–1·46) | 1·20 (0·92–1·58) | 1·54 (1·18–1·99) | 1·1×10−5 |
| FR 2002 | 1·00 | 1·18 (0·70–2·00) | 1·43 (0·87–2·36) | 1·33 (0·79–2·23) | 2·01 (1·24–3·25) | 0·004 |
| Health 2000 | 1·00 | 1·03 (0·63–1·69) | 1·31 (0·81–2·12) | 1·30 (0·80–2·12) | 1·70 (1·08–2·68) | 0·009 |
| MDC-CC | 1·00 | 0·83 (0·57–1·19) | 0·82 (0·57–1·18) | 0·75 (0·51–1·10) | 1·13 (0·80–1·58) | 0·511 |
| Pooled† | 1·00 | 0·95 (0·80–1·12) | 1·10 (0·93–1·29) | 1·16 (0·99–1·36) | 1·50 (1·29–1·75) | 1·9×10−10 |
| HR (95% CI) for MI (total n=29 318) | ||||||
| FR 1992 | 1·00 | 1·00 (0·57–1·73) | 1·00 (0·57–1·77) | 1·60 (0·95–2·69) | 1·45 (0·86–2·44) | 0·039 |
| FR 1997 | 1·00 | 1·02 (0·63–1·65) | 1·36 (0·87–2·11) | 1·32 (0·84–2·08) | 1·87 (1·21–2·87) | 0·002 |
| FR 2002 | 1·00 | 1·22 (0·50–2·95) | 0·89 (0·35–2·26) | 1·16 (0·48–2·81) | 2·05 (0·92–4·60) | 0·095 |
| Health 2000 | 1·00 | 0·89 (0·44–1·81) | 1·68 (0·89–3·17) | 1·00 (0·48–2·05) | 1·35 (0·70–2·62) | 0·320 |
| MDC-CC | 1·00 | 0·93 (0·58–1·51) | 0·78 (0·47–1·28) | 0·89 (0·55–1·46) | 1·03 (0·65–1·64) | 0·891 |
| Pooled† | 1·00 | 0·99 (0·76–1·27) | 1·11 (0·87–1·43) | 1·19 (0·93–1·53) | 1·46 (1·15–1·86) | 2·8×10−5 |
HR=hazard ratio. CHD=coronary heart disease. FR=FINRISK. CVD=cardiovascular disease. MDC-CC=Malmö Diet and Cancer Cardiovascular cohort. MI=myocardial infarction.
*
Association tested with Wald test with a Cox proportional hazards model adjusted for sex, LDL and HDL cholesterol, smoking, body-mass index, systolic and diastolic blood pressure, blood pressure treatment and diabetes; age was used as the timescale.
†
Results were combined with fixed effects meta-analysis.21