Table 4.
Genetic risk score quintile |
p value for trend | |||||
---|---|---|---|---|---|---|
1 (reference) | 2 | 3 | 4 | 5 | ||
OR (95% CI) for CHD (total n=29 318) | ||||||
FR 1992 | 1·00 | 2·30 (0·93–5·69) | 1·22 (0·43–3·40) | 2·67 (1·10–6·46) | 2·13 (0·84–5·36) | 0·117 |
FR 1997 | 1·00 | 0·95 (0·62–1·47) | 0·86 (0·56–1·33) | 0·86 (0·55–1·35) | 1·32 (0·87–2·01) | 0·341 |
FR 2002 | 1·00 | 1·01 (0·60–1·71) | 1·55 (0·96–2·51) | 1·32 (0·79–2·19) | 2·03 (1·26–3·25) | 0·002 |
Health 2000 | 1·00 | 1·56 (0·76–3·22) | 1·67 (0·80–3·47) | 1·96 (0·97–3·99) | 1·58 (0·78–3·23) | 0·184 |
Pooled† | 1·00 | 1·15 (0·86–1·53) | 1·20 (0·90–1·59) | 1·27 (0·95–1·70) | 1·63 (1·24–2·15) | 4·8×10−5 |
OR (95% CI) for CVD (total n=47 179) | ||||||
FR 1992 | 1·00 | 1·7 (0·76–3·78) | 0·95 (0·38–2·38) | 2·49 (1·17–5·29) | 1·69 (0·76–3·80) | 0·090 |
FR 1997 | 1·00 | 0·89 (0·6–1·32) | 0·87 (0·59–1·28) | 0·81 (0·54–1·21) | 1·26 (0·87–1·84) | 0·396 |
FR 2002 | 1·00 | 1·10 (0·71–1·69) | 1·36 (0·90–2·05) | 1·17 (0·76–1·81) | 1·63 (1·09–2·46) | 0·022 |
Health 2000 | 1·00 | 0·97 (0·71–1·33) | 1·12 (0·82–1·53) | 1·04 (0·76–1·42) | 1·16 (0·86–1·57) | 0·275 |
MDC-CC | 1·00 | 1·78 (0·89–3·54) | 2·32 (1·20–4·48) | 1·39 (0·68–2·87) | 1·58 (0·79–3·17) | 0·502 |
MPP | 1·00 | 0·97 (0·82–1·15) | 1·11 (0·94–1·30) | 1·34 (1·14–1·57) | 1·27 (1·08–1·49) | 1·0×10−5 |
Pooled† | 1·00 | 1·01 (0·89–1·15) | 1·13 (1·00–1·28) | 1·24 (1·09–1·40) | 1·30 (1·15–1·47) | 2·6×10−8 |
OR (95% CI) for MI (total n=53 741) | ||||||
FR 1992 | 1·00 | 2·83 (1·00–7·97) | 1·07 (0·30–3·73) | 2·51 (0·88–7·16) | 2·79 (0·98–7·94) | 0·120 |
FR 1997 | 1·00 | 0·95 (0·58–1·56) | 0·76 (0·46–1·27) | 1·08 (0·67–1·76) | 1·01 (0·61–1·68) | 0·807 |
FR 2002 | 1·00 | 0·97 (0·49–1·93) | 1·88 (1·03–3·43) | 1·52 (0·80–2·90) | 1·82 (0·98–3·38) | 0·023 |
Health 2000 | 1·00 | 1·44 (0·54–3·85) | 1·28 (0·45–3·61) | 2·70 (1·09–6·66) | 1·58 (0·61–4·09) | 0·142 |
MDC-CC | 1·00 | 2·35 (0·90–6·18) | 2·39 (0·92–6·22) | 1·51 (0·53–4·27) | 2·97 (1·18–7·50) | 0·092 |
MPP | 1·00 | 1·04 (0·85–1·28) | 1·05 (0·86–1·29) | 1·38 (1·13–1·67) | 1·33 (1·10–1·62) | 1·1×10−5 |
COROGENE | 1·00 | 1·23 (1·03–1·46) | 1·36 (1·14–1·62) | 1·40 (1·18–1·67) | 1·75 (1·48–2·08) | 8·8×10−12 |
Pooled† | 1·00 | 1·16 (1·03–1·31) | 1·22 (1·08–1·38) | 1·40 (1·24–1·58) | 1·56 (1·38–1·76) | 1·2×10−15 |
OR=odds ratio. CHD=coronary heart disease. FR=FINRISK. CVD=cardiovascular disease. MDC-CC=Malmö Diet and Cancer Cardiovascular Cohort. MPP=Malmö Preventive Project. MI=myocardial infarction.
Association tested with Wald test with a logistic regression adjusted for age and sex; COROGENE data with matched case-control design was analysed with conditional logistic regression.
Results were combined with fixed effects meta-analysis.21