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. 2010 Oct 23;376(9750):1393–1400. doi: 10.1016/S0140-6736(10)61267-6

Table 4.

Association between genetic risk score and prevalent coronary heart disease, cardiovascular disease, and myocardial infarction*

Genetic risk score quintile
p value for trend
1 (reference) 2 3 4 5
OR (95% CI) for CHD (total n=29 318)
FR 1992 1·00 2·30 (0·93–5·69) 1·22 (0·43–3·40) 2·67 (1·10–6·46) 2·13 (0·84–5·36) 0·117
FR 1997 1·00 0·95 (0·62–1·47) 0·86 (0·56–1·33) 0·86 (0·55–1·35) 1·32 (0·87–2·01) 0·341
FR 2002 1·00 1·01 (0·60–1·71) 1·55 (0·96–2·51) 1·32 (0·79–2·19) 2·03 (1·26–3·25) 0·002
Health 2000 1·00 1·56 (0·76–3·22) 1·67 (0·80–3·47) 1·96 (0·97–3·99) 1·58 (0·78–3·23) 0·184
Pooled 1·00 1·15 (0·86–1·53) 1·20 (0·90–1·59) 1·27 (0·95–1·70) 1·63 (1·24–2·15) 4·8×10−5
OR (95% CI) for CVD (total n=47 179)
FR 1992 1·00 1·7 (0·76–3·78) 0·95 (0·38–2·38) 2·49 (1·17–5·29) 1·69 (0·76–3·80) 0·090
FR 1997 1·00 0·89 (0·6–1·32) 0·87 (0·59–1·28) 0·81 (0·54–1·21) 1·26 (0·87–1·84) 0·396
FR 2002 1·00 1·10 (0·71–1·69) 1·36 (0·90–2·05) 1·17 (0·76–1·81) 1·63 (1·09–2·46) 0·022
Health 2000 1·00 0·97 (0·71–1·33) 1·12 (0·82–1·53) 1·04 (0·76–1·42) 1·16 (0·86–1·57) 0·275
MDC-CC 1·00 1·78 (0·89–3·54) 2·32 (1·20–4·48) 1·39 (0·68–2·87) 1·58 (0·79–3·17) 0·502
MPP 1·00 0·97 (0·82–1·15) 1·11 (0·94–1·30) 1·34 (1·14–1·57) 1·27 (1·08–1·49) 1·0×10−5
Pooled 1·00 1·01 (0·89–1·15) 1·13 (1·00–1·28) 1·24 (1·09–1·40) 1·30 (1·15–1·47) 2·6×10−8
OR (95% CI) for MI (total n=53 741)
FR 1992 1·00 2·83 (1·00–7·97) 1·07 (0·30–3·73) 2·51 (0·88–7·16) 2·79 (0·98–7·94) 0·120
FR 1997 1·00 0·95 (0·58–1·56) 0·76 (0·46–1·27) 1·08 (0·67–1·76) 1·01 (0·61–1·68) 0·807
FR 2002 1·00 0·97 (0·49–1·93) 1·88 (1·03–3·43) 1·52 (0·80–2·90) 1·82 (0·98–3·38) 0·023
Health 2000 1·00 1·44 (0·54–3·85) 1·28 (0·45–3·61) 2·70 (1·09–6·66) 1·58 (0·61–4·09) 0·142
MDC-CC 1·00 2·35 (0·90–6·18) 2·39 (0·92–6·22) 1·51 (0·53–4·27) 2·97 (1·18–7·50) 0·092
MPP 1·00 1·04 (0·85–1·28) 1·05 (0·86–1·29) 1·38 (1·13–1·67) 1·33 (1·10–1·62) 1·1×10−5
COROGENE 1·00 1·23 (1·03–1·46) 1·36 (1·14–1·62) 1·40 (1·18–1·67) 1·75 (1·48–2·08) 8·8×10−12
Pooled 1·00 1·16 (1·03–1·31) 1·22 (1·08–1·38) 1·40 (1·24–1·58) 1·56 (1·38–1·76) 1·2×10−15

OR=odds ratio. CHD=coronary heart disease. FR=FINRISK. CVD=cardiovascular disease. MDC-CC=Malmö Diet and Cancer Cardiovascular Cohort. MPP=Malmö Preventive Project. MI=myocardial infarction.

*

Association tested with Wald test with a logistic regression adjusted for age and sex; COROGENE data with matched case-control design was analysed with conditional logistic regression.

Results were combined with fixed effects meta-analysis.21