Table 4.
Associations between genetic polymorphisms and NHL overall and histological subtypes risks by vegetable and fruit intake (svgs/d).
| NHL overall |
DLBCL |
FL |
CLL/SLL |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low |
High |
Low |
High |
Low |
High |
Low |
High |
|||||||||
| ca\co | OR (95% CI) | ca\co | OR (95% CI) | ca | OR (95% CI) | ca | OR (95% CI) | ca | OR (95% CI) | ca | OR (95% CI) | ca | OR (95% CI) | ca | OR (95% CI) | |
| Vegetable and fruit | ||||||||||||||||
| MPO (rs4401102) | ||||||||||||||||
| CC | 126 \ 141 | 1 | 108 \ 165 | 1 | 43 | 1 | 37 | 1 | 23 | 1 | 29 | 1 | 20 | 1 | 12 | 1 |
| CT + TT | 86 \ 115 | 0.9(0.6- 1.3) | 121 \ 95 | 1.9(1.3- 2.8) | 22 | 0.7(0.4- 1.3) | 41 | 2.0(1.2- 3.4) | 17 | 0.9(0.5- 1.8) | 33 | 1.9 (1.1-3.5) | 10 | 0.6(0.3- 1.3) | 10 | 1.5(0.6- 3.7) |
| P-interaction | 0.0026 | 0.0052 | 0.1173 | 0.1243 | ||||||||||||
| NOS1 (rs2293054) | ||||||||||||||||
| GG | 108 \ 144 | 1 | 130 \ 108 | 1 | 35 | 1 | 42 | 1 | 13 | 1 | 39 | 1 | 17 | 1 | 10 | 1 |
| AG + AA | 103 \ 112 | 1.2(0.8- 1.7) | 98 \ 152 | 0.5(0.4- 0.8) | 30 | 1.1(0.6- 1.9) | 36 | 0.6(0.4- 1.0) | 26 | 2.7(1.3- 5.6) | 23 | 0.4(0.2- 0.7) | 13 | 1.0(0.5- 2.1) | 11 | 0.7(0.3- 1.9) |
| P-interaction | 0.0024 | 0.1467 | 0.0001 | 0.6042 | ||||||||||||
| NOS1 (rs7298903) | ||||||||||||||||
| TT | 161 \ 215 | 1 | 187 \ 200 | 1 | 50 | 1 | 65 | 1 | 26 | 1 | 55 | 1 | 24 | 1 | 13 | 1 |
| CT + CC | 51 \ 41 | 1.7(1.1- 2.8) | 42 \ 60 | 0.8(0.5- 1.2) | 15 | 1.7(0.8- 3.4) | 13 | 0.7(0.3- 1.3) | 14 | 3.0(1.4- 6.3) | 7 | 0.4(0.2- 1.0) | 6 | 1.3(0.5- 3.5) | 9 | 2.6(1.0- 6.7) |
| P-interaction | 0.0121 | 0.0459 | 0.0003 | 0.3442 | ||||||||||||
| Vegetables | ||||||||||||||||
| NOS1 (rs545654) | ||||||||||||||||
| CC | 68 \ 68 | 1 | 63 \ 66 | 1 | 30 | 1 | 12 | 1 | 11 | 1 | 22 | 1 | 10 | 1 | 7 | 1 |
| CT + TT | 153 \ 183 | 0.8(0.5- 1.2) | 151 \ 192 | 0.8(0.6- 1.3) | 42 | 0.4(0.2- 0.8) | 57 | 1.9(0.9- 3.8) | 31 | 1.0(0.4- 2.1) | 37 | 0.6(0.3- 1.1) | 19 | 0.8(0.3- 1.8) | 16 | 0.8(0.3-2.0) |
| P-interaction | 0.8548 | 0.0028 | 0.3679 | 0.9955 | ||||||||||||
| SOD3 (rs2284659) | ||||||||||||||||
| GG | 75 \ 103 | 1 | 87 \ 95 | 1 | 22 | 1 | 21 | 1 | 19 | 1 | 25 | 1 | 4 | 1 | 14 | 1 |
| GT + TT | 147 \ 148 | 1.5(1.0- 2.2) | 126 \ 164 | 0.8(0.6- 1.2) | 50 | 1.6(0.9- 2.9) | 48 | 1.4(0.8- 2.4) | 24 | 1.0(0.5- 2.0) | 34 | 0.8(0.5-1.5) | 25 | 4.6(1.5-13.7) | 9 | 0.4(0.2-0.9) |
| P-interaction | 0.0463 | 0.578 | 0.7281 | 0.0007 | ||||||||||||
| Red vegetables | ||||||||||||||||
| NOS1 (rs11068446) | ||||||||||||||||
| CC | 174 \ 196 | 1 | 149 \ 185 | 1 | 51 | 1 | 57 | 1 | 38 | 1 | 37 | 1 | 23 | 1 | 1 | |
| CT + TT | 66 \ 53 | 1.5(1.0- 2.3) | 44 \ 73 | 0.8(0.5- 1.2) | 22 | 1.7(0.9- 3.1) | 10 | 0.4(0.2- 0.9) | 17 | 1.9(1.0- 3.8) | 9 | 0.6(0.3- 1.4) | 10 | 1.7(0.7-3.8) | 1.2(0.4- 3.5) | |
| P-interaction | 0.0353 | 0.0057 | 0.0377 | 0.7181 | ||||||||||||
| NOS1 (rs3782221) | ||||||||||||||||
| GG | 126 \ 154 | 1 | 113 \ 134 | 1 | 31 | 1 | 43 | 1 | 29 | 1 | 28 | 1 | 18 | 1 | 3 | 1 |
| AG + AA | 112 \ 96 | 1.4(1.0- 2.1) | 80 \ 121 | 0.8(0.5- 1.2) | 42 | 2.2(1.3- 3.9) | 24 | 0.6(0.3- 1.1) | 24 | 1.5(0.8- 2.8) | 18 | 0.7(0.4- 1.3) | 14 | 1.3(0.6- 2.8) | 15 | 6.3(1.7-22.7) |
| P-interaction | 0.0243 | 0.0011 | 0.1128 | 0.0448 | ||||||||||||
| NOS1 (rs545654) | ||||||||||||||||
| CC | 80 \ 63 | 1 | 50 \ 70 | 1 | 31 | 1 | 10 | 1 | 17 | 1 | 16 | 1 | 10 | 1 | 7 | 1 |
| CT + TT | 158 \ 183 | 0.6(0.4- 0.9) | 140 \ 185 | 1.1(0.7- 1.7) | 41 | 0.4( 0.2- 0.7) | 56 | 2.4(1.1- 5.0) | 37 | 0.6(0.3- 1.2) | 30 | 0.8(0.4- 1.5) | 23 | 0.8(0.4- 1.8) | 11 | 0.7(0.2- 1.8) |
| P-interaction | 0.0593 | 0.0002 | 0.718 | 0.6200 | ||||||||||||
| NOS1 (rs7298903) | ||||||||||||||||
| TT | 186 \ 210 | 1 | 158 \ 197 | 1 | 53 | 1 | 60 | 1 | 40 | 1 | 40 | 1 | 25 | 1 | 12 | 1 |
| CT + CC | 55 \ 40 | 1.6(1.0- 2.6) | 35 \ 61 | 0.7(0.5- 1.2) | 20 | 2.1(1.1- 3.9) | 7 | 0.4(0.2- 0.9) | 15 | 2.3(1.1- 4.7) | 6 | 0.5(0.2- 1.2) | 8 | 1.9(0.8- 4.5) | 6 | 1.7(0.6-4.7) |
| P-interaction | 0.0172 | 0.0015 | 0.0101 | 0.9399 | ||||||||||||
| NOS1 (rs12424669) | ||||||||||||||||
| CC | 201 \ 194 | 1 | 149 \ 202 | 1 | 64 | 1 | 47 | 1 | 40 | 1 | 35 | 1 | 29 | 1 | 16 | 1 |
| CT + TT | 39 \ 55 | 0.6(0.4- 1.0) | 44 \ 55 | 1.1(0.7- 1.7) | 9 | 0.4(0.2- 0.9) | 20 | 1.7(0.9- 3.2) | 15 | 1.2(0.6- 2.3) | 11 | 1.2(0.5- 2.5) | 3 | 0.4(0.1- 1.2) | 2 | 0.5(0.1- 2.3) |
| P-interaction | 0.0961 | 0.0073 | 0.9057 | 0.7909 | ||||||||||||
| NOS2A (rs3729508) | ||||||||||||||||
| CC | 76 \ 103 | 1 | 82 \ 94 | 1 | 20 | 1 | 30 | 1 | 13 | 1 | 19 | 1 | 14 | 1 | 7 | 1 |
| CT + TT | 161 \ 145 | 1.5(1.0- 2.2) | 111 \ 161 | 0.8(0.5- 1.2) | 53 | 2.0(1.1- 3.7) | 37 | 0.7( 0.4- 1.2) | 40 | 2.2(1.1- 4.4) | 27 | 0.8(0.4- 1.6) | 18 | 0.9(0.4- 1.9) | 11 | 0.9(0.3- 2.5) |
| P-interaction | 0.021 | 0.0086 | 0.0445 | 0.9647 | ||||||||||||
| Yellow/orange vegetables | ||||||||||||||||
| NOS1 (rs11068446) | ||||||||||||||||
| CC | 155 \ 205 | 1 | 166 \ 183 | 1 | 49 | 1 | 59 | 1 | 34 | 1 | 40 | 1 | 22 | 1 | 12 | 1 |
| CT + TT | 60 \ 50 | 1.7(1.1- 2.7) | 49 \ 75 | 0.7(0.5- 1.1) | 23 | 2.1(1.1- 3.8) | 10 | 0.4(0.2- 0.9) | 12 | 1.6(0.8- 3.4) | 13 | 0.9(0.4- 1.7) | 9 | 1.9(0.8- 4.5) | 7 | 1.5(0.5- 4.0) |
| P-interaction | 0.0068 | 0.001 | 0.2339 | 0.709 | ||||||||||||
| NOS1 (rs1552227) | ||||||||||||||||
| CC | 93 \ 128 | 1 | 113 \ 117 | 1 | 25 | 1 | 40 | 1 | 20 | 1 | 25 | 1 | 12 | 1 | 12 | 1 |
| CT + TT | 122 \ 128 | 1.3(0.9- 2.0) | 103 \ 141 | 0.8(0.5- 1.1) | 47 | 2.1(1.2- 3.7) | 29 | 0.6(0.3- 1.0) | 26 | 1.4(0.7- 2.6) | 28 | 1.0(0.5- 1.8) | 19 | 1.4(0.6- 3.1) | 7 | 0.5(0.2- 1.3) |
| P-interaction | 0.0195 | 0.0014 | 0.3022 | |||||||||||||
| NOS1 (rs7298903) | ||||||||||||||||
| TT | 163 \ 213 | 1 | 179 \ 200 | 1 | 50 | 1 | 63 | 1 | 36 | 1 | 43 | 1 | 23 | 13 | ||
| CT + CC | 52 \ 43 | 1.7(1.1- 2.8) | 37 \ 58 | 0.7( 0.5- 1.2) | 22 | 2.3(1.2- 4.3) | 6 | 0.3(0.1- 0.8) | 10 | 1.5(0.7- 3.3) | 10 | 0.8(0.4- 1.8) | 8 | 2.1(0.8- 5.2) | 6 | 1.8(0.6- 4.9) |
| P-interaction | 0.0104 | 0.0005 | 0.3115 | 0.8504 | ||||||||||||
Abbreviations: non-Hodgkin lymphoma (NHL); diffuse large B-cell lymphoma (DLBCL); follicular lymphoma (FL); chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL); marginal zone B-cell lymphoma (MZBL); T/NK-cell lymphoma (T-cell); odd ratio (OR); confidence interval (CI); cases (ca); controls (co).
OR (95% CI) were adjusted for age, race (white, other), family history of NHL, total energy intake (kcal), smoking (ever/never), alcohol consumption (gm/day) and body mass index.
Italic P-values <0.05, and italic odd ratios’ 95% confidence intervals do not include 1; Bold P-values are significant after FDR adjustment for multiple comparisons.