Table 1. Common genetic variations in genes involved in LDL-cholesterol metabolism that have an effect on the risk of myocardial infarction.

Gene	Frequency of allele conferring elevated risk	Rise in LDL-cholesterol per copy of allele conferring elevated risk	Effect of allele on risk of myocardial infarction (odds ratio, OR)	p-value for association with myocardial infarction	Reference
PCSK9	80%	+ 15%	OR 1.13	0.004	(21)
Apo E	18%	+ 14%	OR 1.17	0.0001	(21)
LDLR	11%	+ 6%	OR 1.18	0.0001	(19)
Apo B	33%	+ 5%	OR 1.1	0.004	(20)

OR, odds ratio for one allele; PCSK9, proprotein convertase subtilisin/kexin type 9; Apo E, apolipoprotein E; LDLR, low-density lipoprotein receptor; Apo B, apolipoprotein B The differing values for statistical significance are due to large differences in sample size