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. Author manuscript; available in PMC: 2010 Oct 28.
Published in final edited form as: Neuropharmacology. 2007 Aug 15;53(6):771–782. doi: 10.1016/j.neuropharm.2007.08.004

Figure 1.

Figure 1

Effects of l-THP on cocaine self-administration under FR2 reinforcement. Panel A shows representative cocaine self-administration records illustrating that systemic administration of 3 or 10 mg/kg of l-THP increased, while 20 mg/kg inhibited cocaine self-administration. Each vertical line represents a cocaine infusion (0.5 mg/kg/infusion). Panel B shows the mean time courses of cocaine self-administration for the maximal 50 infusions after each dose of l-THP administration. Panel C shows the total numbers of cocaine infusions during the 1st hr of cocaine self-administration. The arrows (↑) indicate the last cocaine infusion. *p<0.05, **p<0.01, ***p<0.001, when compared with the same time point in the vehicle control group (Panel B) or the vehicle (0 mg/kg l-THP) control group (Panel C).