Figure 2.

Risk profile as a function of increasing biomarker severity among all 218 subjects with mild cognitive impairment. Log hazard of progressing to dementia as a function of (A) increasing hippocampal volume (adjusting for total intercranial volumes) and (B) increasing brain Aβ amyloid load within all 218 subjects with mild cognitive impairment. Hash marks at the bottom of the plot indicate the hippocampal volume and Aβ load measures of individual subjects with mild cognitive impairment, with APOE genotype (ε4 carrier gold, non-carrier blue) and progressor versus non-progressor status indicated.