Table 1.
Descriptive characteristics of all 218 subjects with mild cognitive impairment by progressor status, and by Aβ load status
| Characteristic | All | Stablea | Progressor | Amyloid negative (≤1.5) | Amyloid positive (>1.5) |
|---|---|---|---|---|---|
| Number of subjects | n = 218 | n = 129 | n = 89 | n = 53 | n = 165 |
| Female gender, number (%) | 72 (33) | 38 (29) | 34 (38) | 13 (25) | 59 (36) |
| Age, years, median (interquartile range) | 75 (70, 80) | 75 (70, 81) | 75 (70, 80) | 77 (70, 83) | 75 (70, 80) |
| APOE positive, number (%) | 117 (54) | 58 (45) | 59 (66) | 7 (13) | 110 (67) |
| Education, years, median (interquartile range) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) |
| MMSE, median (interquartile range) | 27 (25, 29) | 28 (26, 29) | 26 (25, 28) | 28 (26, 29) | 27 (25, 28) |
| CDR-SB, median (interquartile range) | 1.5 (1.0, 2.0) | 1.0 (1.0, 1.5) | 2.0 (1.0, 2.5) | 1.0 (1.0, 1.5) | 1.5 (1.0, 2.0) |
| Hippocampal volume, cm3, median (interquartile range) | 6.3 (5.6, 7.1) | 6.7 (6.0, 7.5) | 5.9 (5.0, 6.5) | 6.9 (5.6, 7.6) | 6.2 (5.6, 6.8) |
| Aβ, median (interquartile range) | 2.0 (1.5, 2.3) | 1.8 (1.4, 2.2) | 2.2 (1.9, 2.3) | 1.3 (1.3, 1.4) | 2.2 (1.9, 2.4) |
| Number (%) who were amyloid ‘positive’ | 165 (76) | 84 (65) | 81 (91) | 0 (0) | 165 (100) |
| Number (%) in whom Aβ load was measured by PIB PET | 53 (24) | 35 (27) | 18 (20) | 19 (36) | 34 (21) |
CDR-SB = Clinical Dementia Rating-Sum of Boxes; MMSE = Mini-Mental State Examination.
a Subjects remained stable through last follow-up at which point they were censored.