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The effect of Sirt1 inhibition on food intake is UCP2 dependent. Inhibition of brain Sirt1 by EX-527 (30–60 min before dark cycle, 1.5 nmol, i.c.v.) decreased food intake during the dark cycle in wild-type mice, but not in UCP2 KO mice (mean ± SEM, n = 5–12). *p < 0.05.
