Figure 5.

Agrp-Sirt1 KO mice have decreased food intake without concomitant adaptation in energy expenditure. a, Table showing the body weight at weaning and at 11 weeks old in male and female control and Agrp-Sirt1 KO mice. The KO mice gained less weight than controls, which was due mostly to decreased lean mass. Female Agrp-Sirt1 KO mice also showed a diminished fat tissue mass (mean ± SEM, data in grams). b–d, Data from metabolic chambers showing VO₂, VCO₂, and energy expenditure, respectively, adjusted for body mass (kg^−0.75). There were no statistical differences at any of the time points analyzed. In e, data on ambulatory activity of the same mice in the metabolic chambers showing no statistical differences (mean ± SEM, n = 4–7). *p < 0.05.