Table 1.
Minimal inhibitory concentrations (MIC) in vitro and effective concentration (EC50) in vivo of saponins identified in the C.elegans-C. albicans screen.*
| Saponin natural products | MIC in vitro (μg/mL) | EC50in vivo (μg/mL) | |
|---|---|---|---|
| Amphotericin B | 1.0 | 2.0 | |
| A2 | Sakurasosaponin | 27.5 | 55.1 |
| A8 | 5.8 | 23.1 | |
| A16 | Aginoside | 47.0 | 47.0 |
| A24 | 13.3 | 13.3 | |
| A11 | 38.9 | 38.9 | |
| A20 | 4.8 | 4.8 | |
| A7 | 3.1 | 3.1 | |
| A19 | 26.5 | 26.5 | |
| A25 | 28.7 | 28.7 | |
| A17 | 31.0 | 31.0 | |
| A21 | 16.5 | 16.5 | |
*
Compound A6 (Arvensoside B) was unable to provide a MIC or EC50 due to the limited antifungal activity of the compound.