A Model of the Homeostatic Feedback Loop Regulating IAA and Cytokinin Concentrations in the Arabidopsis Root Apex.
Cytokinin (CK) acts as a positive regulator of auxin (IAA) biosynthesis in the root apex, possibly by ATR1 coinduction of the CYP79B2/B3 and NIT3 genes. On the other hand, auxin can act as a repressor of cytokinin biosynthesis via downregulation of specific IPT genes. Both auxin and cytokinin signaling is important for these interactions, and our data suggest that specific auxin/IAA genes (IAA17/AXR3 and IAA3/SHY2) and cytokinin signaling components (AHK4 and ARRs) are involved. Changes in auxin transport (PIN efflux carriers) and in the degradation of auxin (GH3s) and cytokinin (CKXs) may also play important roles in the modulation of the response.